Theory and Practice of Science
Science E1002 -- Summer 2002 -- Blumberg
Final Exam for KR -- Due: July 28, 2002

  
Paper: Muller, H.J. "Variation Due to Change in the Individual Gene."
The American Naturalist 56: 32-50. Electronic edition available
at http://www.esp.org/


Exam: H.J. Muller's 1922 paper provides an important bridge between Mendel, Morgan & Sturtevant; and the later biochemical work that was to lead, starting in the 1940s, to the discovery of the structure of DNA. It encapuslates some of the open questions in genetics while forshadowing a number of later developments. For the purposes of this exam, however, it presents an interesting case study of how far the study (and vocabulary) of genetics had come since Mendel wrote in 1866.

In a clear and well-developed essay of (approx.) 5-10 pages, and using language that would have been understood by Gregor Mendel (i.e. by someone familiar with Mendel's investigations and his paper, and Darwin's published works in the 1860s, but not familiar with any of the notions of molecular biology), summarize Muller's paper in a way that:

As usual, feel free to make use of whatever reference material or classmate expertise you wish, and of course document all your sources.

The direct URL of the paper is : http://www.esp.org/foundations/genetics/classical/holdings/m/hjm-22.pdf



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